Floating Matrix Tablet of Metformin Hydrochloride Using Natural Polymers

Development and in Vitro Evaluation of Sustained Release Floating Matrix Tablets of Metformin Hydrochloride

Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. Metformin hydrochloride, an oral antidiabetic having narrow absorption window in the upper part of gastrointest...

Formulation And In Vitro Evaluation of Colon Targeted Matrix Tablets of Mebeverine Hydrochloride Using Natural Polymers

BACKGROUND: The present study focuses on the design and evaluation of colon targeted matrix tablets of Mebeverine hydrochloride using natural gums like guar gum, xanthan gum at different concentrations. This novel approach is expected to be promising drug delivery system for delivering Mebeverine HCl to the colon for its local action and thereby minimizing systemic side effects of the drug. MET...

Formulation of Controlled Release Pelubiprofen Tablet Using Matrix-Forming Polymers

Influence of Polymers on the Crystal Growth of Metformin Hydrochloride

Crystallization of metformin hydrochloride by solvent evaporation method was carried out in the presence of hydrophilic and hydrophobic polymers to investigate the influence of polymer in the agglomeration of the crystallites in–vitro. Transparent, prismatic shaped crystals (of size: 7 × 2 × 1.5 mm3) were crystallized in hydrophilic polymer hydroxypropyl methylcellulose (HPMC) and long rod shap...

Formulation and Evaluation of Sustained Release Matrix Tablets of Metformin Hydrochloride Using pH Dependent and pH Independent Methacrylate Polymers

Metformin hydrochloride is recommended globally as first line therapy due to its favorable profile on morbidity and mortality associated with type-2 diabetes mellitus. However, limitations of multiple dosing and risk of triggering gastrointestinal symptoms make its dose optimization difficult. Extended-release metformin matrix tablets were prepared by direct compression of drug and different pH...